منابع مشابه
Neuronal polarity.
The assembly of functional neuronal networks in the developing animal relies on the polarization of neurons, i.e., the formation of a single axon and multiple dendrites. Breaking the symmetry of neurons depends on cytoskeletal rearrangements. In particular, axon specification requires local dynamic instability of actin and stabilization of microtubules. The polarized cytoskeleton also provides ...
متن کاملNeuronal polarity in 2011.
Neurons appear to be the most highly polarized cell type in our bodies, often exhibiting a very long axon and highly branched dendrites. How neurons establish and maintain their morphological polarity has fascinated neuroscientists from the time of Cajal, but only recently have we begun to understand the molecular mechanisms that establish and maintain neuro-nal polarity, including both cell-ex...
متن کاملNeuronal Polarity and Trafficking
Among the most morphologically complex cells, neurons are masters of membrane specialization. Nowhere is this more striking than in the division of cellular labor between the axon and the dendrites. In morphology, signaling properties, cytoskeletal organization, and physiological function, axons and dendrites (or more properly, the somatodendritic compartment) are radically different. Such pola...
متن کاملNanotopographic control of neuronal polarity.
We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent co...
متن کاملGeneration and Maintenance of Neuronal Polarity Mechanisms of Transport and Targeting
cell body and dendrites. Indeed, KIFC2, the only known minus end–directed kinesin-like protein, has been shown to localize almost exclusively to the somatodendritic portion of the neurons (Saito et al., 1997). While it remains unclear which organelles are transported by KIFC2, this motor is a good candidate for dendrite-spe-Stanford, California 94305 cific trafficking. However, the predominant ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2011
ISSN: 1932-8451
DOI: 10.1002/dneu.20843